Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Boleng bo Phahameng

Tlhaloso e Khutšoanyane:

Lebitso la Lik'hemik'hale: Remdesivir (GS-5734)

CAS: 1809249-37-3

Ponahalo: Phofo e tiileng e tiileng ho isa ho e tšoeu

Tekanyo: 98.0% ~ 102.0%

Remdesivir bakeng sa kalafo ea COVID-19

API Boleng bo Phahameng, Tlhahiso ea Khoebo

Lipatlisiso: alvin@ruifuchem.com


Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale Remdesivir
Litlhaloso tse tšoanang GS-5734;2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano -3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Nomoro ea CAS 1809249-37-3
Nomoro ea KAtse RF API96
Boemo ba Setoko Ka Setokong, Tlhahiso e Eketseha ho fihla ho Makholo a Lik'hilograma
Foromo ea limolek'hule Setšoantšo sa C27H35N6O8P
Boima ba Molek'hule 602.58
Botenya 1.47±0.1 g/cm3
Brand Ruifu Chemical

Litlhaloso:

Ntho Litlhaloso
Ponahalo Phofo e tiileng e tiileng ho isa ho e tšoeu
Boitsebiso A IR: Maqhubu a ho monya ha infrared a sehlahisoa a lokela ho lumellana le a ntho ea litšupiso.
Boitsebiso B HPLC Nako ea ho boloka e ts'oana le ntho ea litšupiso
Phetoho e khethehileng -19.0° ~ -22.0°
Solubility Solunle ka Methanol, ha e qhibilihe ka har'a Ethanol, ha e qhibilihe hanyenyane ka Acetonitrile, ha e khone ho qhibiliha ka metsing.
Lintho Tse Amanang
Tšilafalo efe kapa efe ea Motho ka Mong ≤0.10%
Litšila ka Kakaretso ≤1.0%
RD-3.1 ≤0.10%
RD-C ≤0.10%
RD-D ≤0.10%
RD-E ≤0.10%
RP-Isomer ≤0.10%
Nitrophenol ≤0.10%
Metsoako e setseng
Methanol Dichloride ≤6000ppm
Acetone ≤5000ppm
Joala ba Isopropyl ≤5000ppm
Acetonitrile ≤410ppm
Dichloromethane ≤600ppm
Methyl tert Butyl Ether ≤5000ppm
Ethyl Acetate ≤5000ppm
Tetrahydrofuran ≤720ppm
n-Heptane ≤5000ppm
Assay 98.0% ~ 102.0% (E baloa ka mokhoa o omisitsoeng)
Kakaretso ea Lipalo tsa Aerobic
Baktheria ea Aerobic ≤100cfu/g
Tomoso le hlobo ≤10cfu/g
E. Koele E mpe
Endotoxin ea baktheria ≤1.0EU
Litšepe tse boima ≤20ppm
Tekanyetso ea Teko Boemo ba Khoebo
Tšebeliso API, COVID-19

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.

Melemo:

1

LBH:

Kopo:

Remdesivir (CAS 1809249-37-3), e rekisoang ka lebitso la Veklury, ke moriana o thibelang likokoana-hloko o pharalletseng o entsoeng ke k'hamphani ea biopharmaceutical Gilead Sciences.E tsamaisoa ka ente ka har'a mothapo.Nakong ea seoa sa COVID-19, remdesivir e ile ea amoheloa kapa ea lumelloa bakeng sa tšebeliso ea tšohanyetso ho phekola COVID-19 linaheng tse ka bang 50.Litaelo tse ntlafalitsoeng ho tsoa ho Mokhatlo oa Lefatše oa Bophelo ka Pulungoana 2020 li kenyelletsa khothaletso e nang le maemo khahlano le ts'ebeliso ea Remdesivir bakeng sa kalafo ea COVID-19.Remdesivir qalong e ne e etselitsoe ho phekola lefu la hepatitis C, mme kamora moo e ile ea fuputsoa bakeng sa lefu la vaerase ea Ebola le ts'oaetso ea vaerase ea Marburg pele e ithutoa joalo ka kalafo ea kamora ts'oaetso bakeng sa COVID-19.Litla-morao tse atileng haholo ho baithaopi ba phetseng hantle ke maemo a phahamisitsoeng a mali a li-enzyme tsa sebete (letšoao la mathata a sebete).Litlamorao tse atileng haholo ho batho ba nang le COVID-19 ke ho nyekeloa ke pelo.Litla-morao li ka kenyelletsa ho ruruha ha sebete le karabelo e amanang le infusion ka ho nyekeloa ke pelo, khatello e tlase ea mali le ho fufuleloa.Remdesivir ke sehlahisoa se reretsoeng ho lumella ho tsamaisoa ha intracellular ea GS-441524 monophosphate le biotransformation e latelang ho GS-441524 triphosphate, ribonucleotide analogue inhibitor ea viral RNA polymerase.

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