5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde CAS 881674-56-2 Vonoprazan Fumarate Intermediate

Tlhaloso e Khutšoanyane:

Lebitso: 5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde

CAS: 881674-56-2

Bohloeki: ≥99.0%

Ponahalo: Powder e mosehla ho ea ho e sootho

Bohareng ba Vonoprazan Fumarate (TAK-438)

Boleng bo Phahameng, Tlhahiso ea Khoebo

Lipatlisiso: alvin@ruifuchem.com


Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale 5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde
Litlhaloso tse tšoanang Vonoprazan Fumarate (TAK-438) Ea Mahareng 3
Nomoro ea CAS 881674-56-2
Nomoro ea KAtse RF-PI330
Boemo ba Setoko Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule C11H8FNO
Boima ba Molek'hule 189.19
Brand Ruifu Chemical

Litlhaloso:

Ntho Litlhaloso
Ponahalo Phofo e Sehla ho ea ho Brown
Melting Point 122.0~131.0℃
Boitsebiso: RT(HPLC) Lumellana le Reference Standard
Tahlehelo Ka Ho Omisa ≤0.50%
Residue On Ignition ≤0.50%
Lintho Tse Amanang
Bohloeki ≥99.0%
Tšilafalo efe kapa efe e le 'Ngoe ≤0.50%
Litšila ka Kakaretso ≤1.0%
Tekanyetso ea Teko Boemo ba Khoebo
Tšebeliso Bohareng ba Vonoprazan Fumarate (TAK-438) (CAS 881681-01-2)

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.

Melemo:

1

LBH:

Kopo:

5-(2-Fluorophenyl) -1H-Pyrrole-3-Carbaldehyde (CAS 881674-56-2) e sebetsa e le reagent ha ho etsoa litokisetso tsa "pyrrole derivatives" e le potassium-competitive acid blocker (P-CAB).5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde ke bohareng ba Vonoprazan Fumarate (CAS 1260141-27-2).Vonoprazan fumarate (Takecab®), e fumanoeng le ho ntlafatsoa ke Takeda le Otsuka, e amohetsoe ke PMDA ea Japane ka December 2014, 'me e bontšoa bakeng sa phekolo ea seso sa ka mpeng, seso sa duodenal le reflux esophagitis.Vonoprazan fumarate e na le mokhoa o mocha oa ts'ebetso o bitsoang li-blocker tsa potassium-competitive acid, tse thibelang ka tlholisano ho tlama li-ion tsa potassium ho H+, K+ -ATPase (eo hape e tsejoang e le pompo ea proton) mohatong oa ho qetela oa secretion ea asiti ea gastric ka har'a lisele tsa parietal tsa ka mpeng.Vonoprazan ha e thibele mosebetsi oa Na +, K + -ATPase esita le ka makhetlo a 500 a phahameng ho feta a litekanyetso tsa bona tsa IC50 khahlanong le mosebetsi oa gastric H +, K + -ATPase.Ho feta moo, sethethefatsi ha se amehe ke boemo ba lekunutu ba gastric, ho fapana le li-PPI.

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