4,6-Dimethyl-2-(Methylsulfonyl)pyrimidine CAS 35144-22-0 Purity ≥99.0% (HPLC) Factory

Short Description:

4,6-Dimethyl-2-(Methylsulfonyl)pyrimidine

CAS: 35144-22-0

Appearance: Yellow Crystalline Powder

Purity: ≥99.0% (HPLC)

Intermediate of API (CAS: 177036-94-1) in the treatment of Pulmonary Arterial Hypertension (PAH) 

Contact: Dr. Alvin Huang 

Mobile/Wechat/WhatsApp: +86-15026746401  

E-Mail: alvin@ruifuchem.com 


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35144-22-0 - Description:

35144-22-0 - Chemical Properties:

Chemical Name 4,6-Dimethyl-2-(Methylsulfonyl)pyrimidine
Abbreviation DLMSP; 4,6-Dimethyl-2-(Methylsulfonyl)pyrimidine; 2-Methanesulfonyl-4,6-Dimethylpyrimidine; 2-(Methylsulfonyl)-4,6-Dimethylpyrimidine
CAS Number 35144-22-0
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C7H10N2O2S
Molecular Weight 186.23 
Melting Point 80.0~84.0℃
Density 1.239g/cm3
Solubility (Soluble in) Methanol
COA & MSDS Available
Sample Available
Origin Shanghai, China
Brand Ruifu Chemical

35144-22-0 - Specifications:

Item Specifications Specifications
Appearance Yellow Crystalline Powder Yellow Crystalline Powder
Purity / Analysis Method ≥99.0% (HPLC) 99.60% 
Melting Point 80.0~84.0℃ 80.0~82.0℃
Moisture (K.F) ≤0.50%  0.33% 
Residue on Ignition ≤0.30% 0.09%
Single Impurity ≤0.50%  <0.50% 
Heavy Metals ≤20ppm <20ppm
1 H NMR Spectrum Consistent with Structure Complies
Conclusion The product has been tested and complies with the given specifications
Main Application  Intermediate of API (CAS: 177036-94-1) 

4,6-Dimethyl-2-(Methylsulfonyl)pyrimidine (CAS: 35144-22-0) Synthetic Route

35144-22-0

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

1

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35144-22-0 - Risk and Safety:

Hazard Symbols Xi - Irritant
Risk Codes
36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.

35144-22-0 - Application:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 4,6-Dimethyl-2-(Methylsulfonyl)pyrimidine (CAS: 35144-22-0) with high quality. It's a pharmaceutical Intermediate can be used in the synthesis of API (CAS: 177036-94-1). (CAS: 177036-94-1) is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. It is the third ET-receptor antagonist to be marketed for this indication behind bosentan and sitaxsentan. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and ultimately, right ventricular failure and premature death. Early symptoms of PAH include gradual onset of shortness of breath, fatigue, palpitation, edema, and fainting.

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